منابع مشابه
Gene therapy for restenosis.
Gene Therapy for Restenosis Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.86.8.829 2000;86:829-833 Circ Res. http://circres.ahajournals.org/content/86/8/829 World Wide Web at: The online version o...
متن کاملGene Therapy for Restenosis.
a multifactorial problem consisting of cell proliferation, extracellular matr ix formation, thrombosis and chronic remodeling of the vessel wall. To prevent restenosis, vascular gene transfer strategies have been developed to limit cellular proliferation and intimal formation. Vascular gene transfer is the transfer of foreign or native genes into vascular cells to modulate gene expression. Earl...
متن کاملGene therapy of restenosis: promise and perils.
The advent of technology for vascular gene transfer some 8 years ago led to an explosion of interest in the notion that local gene therapy could modify the natural history of arterial hyperplastic diseases. What better testing ground for this concept than restenosis following percutaneous transluminal coronary angioplasty (PTCA) or other arterial interventions? In this situation, the precise mo...
متن کاملGene therapy for restenosis: are we ready?
The application of gene therapy techniques to the clinical problem of coronary restenosis has generated tremendous attention and enthusiasm. Use of gene transfer technology to prevent a common intractable illness would represent a watershed event for human gene therapy. However, the time is not yet right to initiate gene therapy trials for restenosis. The biology of restenosis is incompletely u...
متن کاملGene Therapy for Restenosis: Progress or Frustration?
No systemic pharmacological treatment has been shown to convincingly reduce the incidence of restenosis after angioplasty in patients. The lack of success of many pharmaceutical agents in reducing restenosis rates post-angioplasty and following stent-implementation shown in dozens of clinical trials has encouraged the development of new technological approaches as treatment. Gene therapy has th...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1998
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.82.3.404